SITASMART 50 (50mg/1000mg Sitagliptin/Metformin)

Product Information

SITASMART contains two active ingredients: Sitagliptin (a DPP-4 inhibitor) and Metformin hydrochloride (a biguanide). It is an oral anti-hyperglycemic (anti-diabetic) medicine used to help reduce blood sugar levels in people with type 2 diabetes.

• Sitagliptin works by increasing insulin secretion and reducing glucagon release from the pancreas, which helps lower blood glucose without causing hypoglycemia.

• Metformin decreases glucose production by the liver, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing glucose uptake and utilization.

SITASMART is available in various strengths, including 50 mg + 1000 mg tablets, and is manufactured by Sun Pharma, India.

Why is this Medication Prescribed?

SITASMART is prescribed to improve blood sugar control in adults with type 2 diabetes mellitus, particularly when diet and exercise alone are not sufficient. It helps reduce long-term complications of diabetes, such as heart disease, kidney damage, and nerve problems.

Uses

• Management of type 2 diabetes mellitus

• Reduction of blood glucose when single-agent therapy with Metformin or Sitagliptin is insufficient

Benefits

• Provides dual action by combining two complementary mechanisms:
  • Sitagliptin: enhances insulin release and lowers glucagon

  • Metformin: reduces glucose production and improves insulin sensitivity

• Helps maintain stable blood glucose levels

• Reduces risk of hypoglycemia compared with some other antidiabetic medicines

• Supports long-term diabetes control when combined with lifestyle measures

How Should this Medicine be Used?

• Take SITASMART by mouth exactly as prescribed by your doctor.

• Usually taken with meals to reduce the risk of stomach upset.

• Take it at the same time(s) each day for best effect.

• Do not stop taking SITASMART without consulting your doctor.

Other Uses

Currently, SITASMART is used only for the treatment of type 2 diabetes.

🍷 Alcohol Warning

Do not drink alcohol while taking SITASMART. Combining alcohol with Metformin may increase the risk of lactic acidosis, a rare but serious complication.

• Avoid both heavy and occasional binge drinking.

• Symptoms of lactic acidosis include muscle pain, severe weakness, stomach discomfort, trouble breathing, unusual drowsiness, or rapid breathing.

• Seek emergency medical help immediately if these symptoms occur.

Special Precautions

Before taking SITASMART, inform your doctor if you have:

• Kidney disease or reduced kidney function

• Liver disease

• Heart failure or other heart conditions

• History of lactic acidosis

• Heavy alcohol use

Important precautions:

• Your doctor may order regular blood tests to monitor kidney and liver function.

• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Possible Side Effects

Common side effects:

• Nausea

• Vomiting

• Diarrhea

• Stomach upset

• Headache

• Upper respiratory tract infection

Serious but less common side effects:

• Lactic acidosis (rare but serious; symptoms include muscle pain, severe weakness, trouble breathing, unusual sleepiness, abdominal pain)

• Low vitamin B12 levels with long-term use of Metformin

• Severe allergic or skin reactions

Seek medical help if you notice symptoms of lactic acidosis or severe allergic reactions.

Storage & Disposal

• Store at room temperature, away from moisture and heat.

• Keep out of reach of children and pets.

• Do not use after the expiration date.

• Dispose of unused or expired medicine safely, following pharmacist or local disposal guidelines.

Emergency Guidance

• Overdose: Contact your doctor or poison control center immediately. Symptoms may include severe weakness, vomiting, rapid breathing, or confusion (possible lactic acidosis).

• Allergic reaction: Seek emergency help if you experience rash, itching, swelling of face/tongue/throat, severe dizziness, or difficulty breathing.

• Severe side effects: Go to the nearest emergency department if you develop lactic acidosis symptoms or any life-threatening reaction.