LEETREXATE 10 (10mg Methotrexate)

Product Information

Leetrexate 10mg Tablet is used to treat rheumatoid arthritis and severe psoriasis.

• In rheumatoid arthritis, it helps prevent further joint damage.
• In psoriasis, it slows the growth of skin cells and controls symptoms.

Leetrexate may be used alone or in combination with other medicines. It must be taken exactly as advised by your doctor.

• Do not take more than prescribed—excessive doses can cause serious side effects.
• Benefits may take several weeks to months to appear.
• Do not stop treatment without your doctor’s guidance.
• Avoid alcohol while on this medicine as it increases the risk of liver damage.

Why is this Medication Prescribed?

Leetrexate is prescribed to:

• Control severe rheumatoid arthritis and reduce further joint damage.
• Treat severe, resistant psoriasis by slowing down abnormal skin cell growth.

Uses

• Treatment of Rheumatoid Arthritis

• Treatment of Psoriasis

Benefits

In Rheumatoid Arthritis

• Reduces immune system overactivity.
• Decreases swelling, pain, and stiffness.
• Improves physical function and prevents further joint damage.
• Provides benefit over long-term treatment, though it may take months to become fully effective.

In Psoriasis

• Controls rapid skin cell turnover.
• Reduces scaling, redness, and inflammation.
• Used when other therapies have failed.
• Potent medicine—benefits and risks should be carefully discussed with your doctor.

How Should this Medicine be Used?

• Take exactly as prescribed by your doctor.
• Do not exceed the recommended dose.

• Treatment may take several months before full benefit is seen.
• Drink plenty of water to stay hydrated.
• Avoid alcohol during treatment.

⚠️ Pregnancy & Birth Defect Risk Warning

This medicine may cause serious harm to an unborn baby, including birth defects or pregnancy loss.

• Do not take this medicine if you are pregnant or planning a pregnancy.
• Use effective contraception during treatment and for the duration specified by your doctor after stopping.
• If you become pregnant while taking this medicine, stop it immediately and contact your doctor.

⚠️ Liver Toxicity Warning

This medicine may cause liver damage. Your doctor may monitor your liver function with blood tests.

• Stop taking the medicine and seek medical help if you develop yellowing of the skin or eyes, dark urine, persistent nausea, vomiting, or abdominal pain.
• Avoid alcohol while taking this medicine to reduce liver risk.

⚠️ Immune System Suppression Warning

This medicine weakens your immune system and increases the risk of infections.

• Avoid close contact with people who have infections.
• Report fevers, chills, persistent cough, or unusual symptoms promptly.
• Live vaccines should not be taken during treatment unless approved by your doctor.

Special Precautions

Before taking Leetrexate, tell your doctor if you:

• Are pregnant, planning pregnancy, or breastfeeding (not recommended, may harm the baby).
• Have liver, kidney, or stomach problems.
• Are taking medicines for infections or other chronic conditions.
• Are scheduled for any vaccinations.

Regular monitoring (blood tests, imaging, and examinations) is required during treatment to check for side effects affecting blood, liver, kidneys, or lungs.

Possible Side Effects

Common side effects include:

• Abdominal pain
• Indigestion
• Loss of appetite
• Nausea and vomiting
• Mouth sores
• Fatigue or tiredness

Your doctor may recommend folic acid supplementation to reduce some side effects.

Storage & Disposal

• Store in a cool, dry place away from light and moisture.
• Keep out of reach of children and pets.
• Do not use after the expiry date.
• Dispose of unused tablets safely—do not flush or throw in household waste. Ask your pharmacist about proper disposal.

Emergency Guidance

• Overdose: Seek emergency medical help immediately if you take more than the prescribed dose. Overdose can cause severe, life-threatening toxicity.
• Severe reactions: Go to the emergency department if you develop yellowing of skin/eyes, severe mouth ulcers, difficulty breathing, fever, or uncontrolled bleeding.
• Allergic reaction: Seek urgent care if you experience rash, itching, swelling of face/tongue/throat, or difficulty breathing.